Final post for 2013

TFconcOne of our most exciting stories that we’ve worked on for the past couple of months was Daphne Ezer’s project on physical constraints in bacterial promoter architecture. We analysed E. coli promoters and looked at the influence of TF affinity, TF concentration, and the relative location of TF binding sites (orientation, distance between) on gene expression, under special consideration of facilitated diffusion (the mode of TF translocation on and along the DNA, see our review). Our manuscript was accepted over the holidays, and if you’re really keen, you can get a preview on arXiv: Physical constraints determine the logic of bacterial promoter architectures.

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