New publication

PLoS_Schep_teaserOur paper A Comparative Analysis of Transcription Factor Expression during Metazoan Embryonic Development by Alicia Schep and myself is finally out in PLoS ONE. This work was our first “experiment” that we put out on arXive before embarking on final publication in a peer-reviewed journal. This will probably also tell you something about the time line of scientific publishing: We submitted on arXive on 8th January and to PLoS ONE on 9th January. With reviewers taking their time and a revision, the final manuscript is online today, almost six months later.

What else is to say? Ah, the science: We looked at gene expression profiles for transcription factors of representatives of vertebrates (Danio rerio, Xenopus tropicalis), a chordate (Ciona intestinalis) and invertebrate phyla such as insects (Drosophila melanogaster, Anopheles gambiae) and nematodes (Caenorhabditis elegans). We clustered TFs for each species based on their quantitative temporal expression profiles. This showed very similar TF expression trends in development in vertebrate and insect species. However, analysis of the expression of orthologous pairs between more closely related species showed that expression of most individual TFs is not conserved, following the general model of duplication and diversification.

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