Pushing the limits of biology

It’s not always big news that excites us. In their recent newsletter, the Prime-XS Consortium features an article Pushing the limits of biology. It’s an introduction into the cutting-edge proteomics that the Functional Genomics Centre Zurich does for their Prime-XS partners. Under the heading Next-generation proteomics they report about their work with [...]

Royal Society URF Conference 2014

A lot of the freedom that I have in my work (pursuing research in fly developmental biology, computational studies on bacterial gene regulation, and even my application of microelectronics for teaching purposes) comes from being a Royal Society University Research Fellow (URF). These fellowships give scientists between five and, under exceptional circumstances, ten [...]

Sorry, we are full.

We’ve had a successful 2013 and that apparently hasn’t gone unnoticed. This December alone, we’ve received more applications for summer projects than in all of lent. This is particularly true for the Amgen Scholarship, for which we have chosen a candidate, and Erasmus internships. Therefore, please, do not send any more applications [...]

Final post for 2013

One of our most exciting stories that we’ve worked on for the past couple of months was Daphne Ezer’s project on physical constraints in bacterial promoter architecture. We analysed E. coli promoters and looked at the influence of TF affinity, TF concentration, and the relative location of TF binding sites (orientation, distance between) [...]

New publication

Our manuscript “The Influence of Transcription Factor Competition on the Relationship between Occupancy and Affinity” has now been published in PLoS ONE. We summarised the main findings in a few other blog posts, and it’s not a long one, so why don’t you have a quick read of the abstract at PLoS. [...]

New publication

Our manuscript “The effects of transcription factor competition on gene regulation“ was just published in Frontiers in Systems Biology in the special issue on The origins of biological noise after a whooping 36 days between first submission and acceptance. We discuss the influence of TF abundance on the arrival time of TFs on [...]

Prime-XS and Royal Society Funding

Already a good few months ago we’ve secured support from Prime-XS, a EU-funded consortium that provides free access to state-of-the-art mass-spectroscopy infrastructure. While this grant pays for sample preparation and handling, instrument time and some basic initial analysis, a few of the questions that really interest us require the purchase of very [...]

(Another) Return of the JEDI

I’m gearing up for the 3rd Junior European Drosophila Investigator meeting, to be held at Cumberland Lodge near London from Wednesday (14/8/) to Friday (16/8/) this week. This time the meeting is organized by Barry Thompson, Giorgio Gilestro and myself — although Giorgio and I mostly just said “alright, go ahead, Barry” to this [...]

Donation from ARM

Being a geek but also a teacher, a few months ago I attended a Train-the-trainer workshop in mbed programming at the ARM headquarters here in Cambridge. I learned about the mbed platform, which, in lay terms, is a little bit like Arduino for industrial purposes: With more horsepower and to be programmed [...]

Summer student studies

Over the past few weeks we have been joined by a handful of summer students: Armin Schöch (MPhil student in Computational Biology), Busra Erarslan (Erasmus student from Turkey) and Juliet Handsaker (Amgen Scholar from University of Warwick).

Summer students are an exciting business. They’re usually in the lab for too [...]